Mammalian basic HLH (helix–loop–helix)–PER–ARNT–SIM (bHLH–PAS) proteins are
heterodimeric transcription factors that sense and respond to environmental signals (such as …

Targeting protein–protein interactions (PPIs) has emerged as a viable approach in modern
drug discovery. However, the identification of small molecules enabling us to effectively …

The hypoxia-inducible factors (HIFs) coordinate cellular adaptations to low oxygen stress by
regulating transcriptional programs in erythropoiesis, angiogenesis and metabolism. These …

The small GTPase Ran regulates the interaction of transport receptors with a number of
cellular cargo proteins. The high affinity binding of the GTP-bound form of Ran to import …

Neuronal PER-ARNT-SIM (PAS) domain protein 4 (NPAS4) is a protective transcriptional
regulator whose dysfunction has been linked to a variety of neuropsychiatric and metabolic …

Abstract Hypoxia-inducible factor-2 (HIF-2) is a heterodimeric transcription factor formed
through dimerization between an oxygen-sensitive HIF-2α subunit and its obligate partner …

Animals respond to chronic hypoxia by increasing the levels of a transcription factor known
as the hypoxia‐inducible factor (HIF). HIF upregulates multiple genes, the products of which …

Mammalian circadian timekeeping arises from a transcription-based feedback loop driven
by a set of dedicated clock proteins. At its core, the heterodimeric transcription factor …

Circadian rhythms are genetically encoded molecular clocks for internal biological
timekeeping. Organisms from single-cell bacteria to humans use these clocks to adapt to the …

Pharmacological inhibition of uncontrolled cell growth with small-molecule inhibitors is a
potential strategy for treating glioblastoma multiforme (GBM), the most malignant primary …