Aneuploidy, a genomic alternation characterized by deviations in the copy number of
chromosomes, affects organisms from early development through to aging. Although it is a …

Animal models refers to the animal experimental objects and related materials that can
simulate human body established in medical research. As the second-largest disease in …

Introduction Acquired cancer therapy resistance evolves under selection pressure of
immune surveillance and favors mechanisms that promote drug resistance through cell …

The ability to monitor the environment for toxic chemical and physical disturbances is
essential for bacteria that live in dynamic environments. The fundamental sensing …

The early development of aneuploidy from an accidental chromosome missegregation
shows contrasting effects. On the one hand, it is associated with significant cellular stress …

Along with various experimental methods, a combination of theoretical and computational
methods is essential to explore different length-scale and time-scale processes in the …

Single cells actively coordinate growth and division to regulate their size, yet how this size
homeostasis at the single-cell level propagates over multiple generations to impact clonal …

Abstract Whenever applicable, the Stochastic Gradient Descent (SGD) has shown itself to be
unreasonably effective. Instead of underperforming and getting trapped in local minima due …

Intratumour phenotypic heterogeneity is nowadays understood to play a critical role in
disease progression and treatment failure. Accordingly, there has been increasing interest in …

We consider evolution of a large population, where fitness of each organism is defined by
many phenotypical traits. These traits result from expression of many genes. Under some …