A quaternary carbon bears four other carbon substituents or combination of four non-
hydrogen substituents at four vertices of a tetrahedron. The spirocyclic quaternary carbon …

Conspectus One of the simplest questions that can be asked about molecular diversity is
how many organic molecules are possible in total? To answer this question, my research …

Covering: up to 2021 The structural core of most small-molecule drugs is formed by a ring
system, often derived from natural products. However, despite the importance of natural …

The chemical space is the ensemble of all possible molecules, which is believed to contain
at least 1060 organic molecules below 500 Da of possible interest for drug discovery. This …

Using a diverse collection of small molecules generated from a variety of sources, we
measured protein-binding activities of each individual compound against each of 100 …

Natural products have made significant contribution to cancer chemotherapy over the past
decades and remain an indispensable source of molecular and mechanistic diversity for …

Because of their unique effects and relatively low side effects, herbal medicine has been
gaining popularity all over the world. Quality control is a challenge to ensure safety, efficacy …

Virtual screening is increasingly being used in drug discovery programs with a growing
number of successful applications. Experimental methodologies developed to speed up the …

The DNA methyltransferase (DNMT) enzyme family consists of four members with diverse
functions and represents one of the most promising targets for the development of novel …

Natural products have a significant role in drug discovery. Natural products have distinctive
chemical structures that have contributed to identifying and developing drugs for different …