Human serotine transporter (hSERT) is one of the most influential drug targets, and its
allosteric modulators (eg, escitalopram) have emerged to be the next-generation medication …

Solute carrier transporters (SLCs) are a class of important transmembrane proteins that are
involved in the transportation of diverse solute ions and small molecules into cells. There are …

Serotonin (5-HT) is a vital modulatory neurotransmitter responsible for regulating most
behaviors in the brain. An inefficient 5-HT synaptic function is often linked to various mental …

The human serotonin transporter (hSERT) terminates neurotransmission by removing
serotonin (5HT) from the synaptic cleft, an essential process for proper functioning of …

Anecdotal reports and open-label case studies in humans indicated that the psychedelic
alkaloid ibogaine exerts profound antiaddictive effects. Ample preclinical evidence …

In a previous study, we demonstrated that the hydro extract of Mao Jian Green Tea (MJGT)
promotes gastrointestinal motility. In this study, the effect of MJGT ethanol extract (MJGT_EE) …

The human serotonin transporter (hSERT) terminates serotonergic signaling through
reuptake of neurotransmitter into presynaptic neurons and is a target for many …

Selective serotonin reuptake inhibitor (SSRI) antidepressants are commonly prescribed
treatments for depression, but their effects on serotonin reuptake and release are not well …

The human dopamine transporter (hDAT) is one in three members of the monoamine
transporter family (MAT). hDAT is essential for regulating the dopamine concentration in the …

Cocaine use disorder (CUD) is a significant public health issue that generates substantial
personal, familial, and economic burdens. Still, there are no FDA-approved …