It is widely acknowledged that the climacteric syndrome negatively affects women's quality of
life and leads to cerebral ischemic injury, osteoporosis and cardiovascular disease. One of …

The epididymis, a key reproductive organ, is crucial for sperm concentration, maturation, and
storage. Despite a comprehensive understanding of many of its functions, several aspects of …

Progesterone receptors (PRs) are implicated in various cancers since their
presence/absence can determine clinical outcomes. The overstimulation of progesterone …

Epididymal development can be subdivided into three phases: undifferentiated, a period of
differentiation, and expansion. The objectives of this study were (1) to assess gene …

Health is strongly affected by aging and lifespan-modulating interventions, but the molecular
mechanisms of mortality regulation remain unclear. Here, we conducted an RNA-seq …

The development of antiprogestins was initially a gynecological purpose. However, since
mifepristone was developed, its application for breast cancer treatment was immediately …

Progesterone receptor antagonism is gaining attention due to progesterone's recognized
role as a major mitogen in breast tissue. Limited but promising data suggest the potential …

The origin of breast cancer (BC) has traditionally been a focus of medical research. It is
widely acknowledged that BC originates from immortal mammary stem cells and that these …

Breast cancer is a common and deadly disease, so there is a constant need for research to
find efficient targets and therapeutic approaches. Breast cancer can be classified on a …

The Adriamycin (ADR) nephropathy model, which induces podocyte injury, is limited to
certain mouse strains due to genetic susceptibilities, such as the PrkdcR2140C …