Mounting evidence has firmly established that low levels of cardiorespiratory fitness (CRF)
are associated with a high risk of cardiovascular disease, all-cause mortality, and mortality …

Basal metabolic rate (BMR) provides a widely accepted benchmark of metabolic
expenditure for endotherms under laboratory and natural conditions. While most studies …

Statistics from the American Heart Association (AHA) emphasizes the continuing burden of
cardiovascular disease (CVD) in the United States, with a prevalence of CVD nearing 40 …

Regular exercise promotes whole-body health and prevents disease, but the underlying
molecular mechanisms are incompletely understood,–. Here, the Molecular Transducers of …

Physical activity plays an important role in preventing chronic disease in adults and the
elderly. Exercise has beneficial effects on the nervous system, including at the …

At high-altitude, small mammals are faced with the energetic challenge of sustaining
thermogenesis and aerobic exercise in spite of the reduced O2 availability. Under conditions …

A paradigm shift in neuroscience was the discovery that new neurons are constantly
produced in the adult mammalian brain of several species, including Homo sapiens. These …

The hunting and gathering lifestyle adopted by human ancestors around 2 Ma required a
large increase in aerobic activity. High levels of physical activity altered the shape of the …

Sports genetics can take advantage of lessons learned from human disease genetics. By
righting past mistakes and increasing scientific rigor, we can magnify the breadth and depth …

Exercise capacity has been related to morbidity and mortality. It consists of an inherited and
an acquired part and is dependent on mitochondrial function. We assessed skeletal muscle …