Perineuronal nets (PNNs) are condensed extracellular matrix (ECM) structures found
throughout the central nervous system that regulate plasticity. They consist of a …

Quantifying how the cellular composition of brain regions vary across development, aging,
sex, and disease, is crucial in experimental neuroscience, and the accuracy of different …

Parvalbumin (PV) neurons play an integral role in regulating neural dynamics and plasticity.
Therefore, understanding the factors that regulate PV expression is important for revealing …

Perineuronal nets (PNNs) are densely packed extracellular matrices that cover the cell body
of fast-spiking inhibitory neurons. PNNs stabilize synapses inhibiting synaptic plasticity …

The brain extracellular matrix (ECM) has garnered increasing attention as a fundamental
component of brain function in a predominantly “neuron‐centric” paradigm. Particularly, the …

Substance use disorders are a global health problem with increasing prevalence resulting in
significant socioeconomic burden and increased mortality. Converging lines of evidence …

Biological sex influences decision-making processes in significant ways, differentiating the
responses animals choose when faced with a range of stimuli. The neurobiological …

Microglia continuously remodel synapses, which are embedded in the extracellular matrix
(ECM). However, the mechanisms, which govern this process remain elusive. To investigate …

Alzheimer's disease (AD) and schizophrenia (SCZ) represent two major neuropathological
conditions with a high disease burden. Despite their distinct etiologies, patients suffering …

Cortical parvalbumin interneurons (PV+) are major regulators of excitatory/inhibitory
information processing, and their maturation is associated with the opening of …