Wnt signaling is an evolutionary cell‐to‐cell coordination mechanism and it is highly critical
for a variety of physiological processes of an organism's body, including stem cell …

Signaling by the Wnt family of secreted glycolipoproteins via the transcriptional coactivator β-
catenin controls embryonic development and adult homeostasis. Here we review recent …

Hepatocytes, the major metabolic hub of the body, execute functions that are human-
specific, altered in human disease, and currently thought to be regulated through endocrine …

The WNT16 locus is a major determinant of cortical bone thickness and nonvertebral
fracture risk in humans. The disability, mortality and costs caused by osteoporosis-induced …

Wnt plays important role during development and in various diseases. Because Wnts are
lipidated and highly hydrophobic, they can only be purified in the presence of detergents …

Wnt signaling is activated by wounding and participates in every subsequent stage of the
healing process from the control of inflammation and programmed cell death, to the …

Epithelial tissues require the removal and replacement of damaged cells to sustain a
functional barrier. Dying cells provide instructive cues that can influence surrounding cells to …

The receptor class Frizzled, which has recently been categorized as a separate group of G
protein-coupled receptors by the International Union of Basic and Clinical Pharmacology …

The Wnt signaling pathway plays a central role in bone development and homeostasis. In
most cases, Wnt ligands promote bone growth, which has led to speculation that Wnt factors …

Wnt/β-catenin signaling is initiated at the cell surface by association of secreted Wnt with its
receptors Frizzled (Fz) and low density lipoprotein receptor-related protein 5/6 (LRP5/6). The …