Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

Highlights•As a quickly expanding and diverse class of natural products, RiPPs are an
excellent target to find leads for new drugs.•New gene clusters can be identified using …

The ribosomally synthesized and post-translationally modified peptide (RiPPs) class of
natural products has undergone significant expansion due to the rapid growth in genome …

Peptide natural products are important lead structures for human drugs and many
nonribosomal peptides possess antibiotic activity. This makes them interesting targets for …

Lanthipeptides are a major class of ribosomally synthesized and post-translationally
modified peptides (RiPPs) characterized by thioether cross-links called lanthionine (Lan) …

Naturally occurring lanthipeptides, peptides post-translationally modified by various
enzymes, hold significant promise as antibiotics. Despite extensive biochemical and …

Lanthipeptides are ribosomally‐synthesized natural products from bacteria featuring stable
thioether‐crosslinks and various bioactivities. Herein, we report on a new clade of tricyclic …

Aminovinyl-cysteine (AviCys) is a thioether amino acid shared by a variety of ribosomally
synthesized and posttranslationally modified peptides (RiPPs). Based on investigations into …

In nature, peptides are enzymatically modified to constrain their structure and introduce
functional moieties. De novo peptide structures could be built by combining enzymes from …

A large number of antimicrobial peptides depend on intramolecular disulfide bonds for their
biological activity. However, the relative instability of disulfide bonds has limited the potential …