Trial design and endpoints in hepatocellular carcinoma: AASLD consensus conference

JM Llovet, A Villanueva, JA Marrero, M Schwartz… - …, 2021 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related mortality
worldwide.(1, 2) This neoplasm has some unique characteristics. It occurs in most cases …

Epidemiology of hepatocellular carcinoma: target population for surveillance and diagnosis

A Tang, O Hallouch, V Chernyak, A Kamaya… - Abdominal …, 2018 - Springer
Hepatocellular carcinoma (HCC) is the sixth most common cancer and the second leading
cause of cancer mortality worldwide. Incidence rates of liver cancer vary widely between …

EASL–EORTC clinical practice guidelines: management of hepatocellular carcinoma

European Association For The Study Of … - Journal of …, 2012 - journal-of-hepatology.eu
EASL–EORTC Clinical Practice Guidelines (CPG) on the management of hepatocellular
carcinoma (HCC) define the use of surveillance, diagnosis, and therapeutic strategies …

[HTML][HTML] EASL–EORTC clinical practice guidelines: management of hepatocellular carcinoma

EO for Research… - Journal of …, 2012 - Elsevier
EASL–EORTC Clinical Practice Guidelines (CPG) on the management of hepatocellular
carcinoma (HCC) define the use of surveillance, diagnosis, and therapeutic strategies …

Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo …

AL Cheng, YK Kang, Z Chen, CJ Tsao, S Qin… - The lancet …, 2009 - thelancet.com
Background Most cases of hepatocellular carcinoma occur in the Asia-Pacific region, where
chronic hepatitis B infection is an important aetiological factor. Assessing the efficacy and …

Sorafenib in advanced hepatocellular carcinoma

JM Llovet, S Ricci, V Mazzaferro… - New England journal …, 2008 - Mass Medical Soc
Background No effective systemic therapy exists for patients with advanced hepatocellular
carcinoma. A preliminary study suggested that sorafenib, an oral multikinase inhibitor of the …

Current strategy for staging and treatment: the BCLC update and future prospects

A Forner, ME Reig, CR de Lope… - Seminars in liver …, 2010 - thieme-connect.com
Staging and treatment indication are relevant topics in the management of patients with
hepatocellular carcinoma (HCC) and for optimal results, they have to take into account liver …

Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma

M Omata, LA Lesmana, R Tateishi, PJ Chen… - Hepatology …, 2010 - Springer
Abstract Introduction The Asian Pacific Association for the Study of the Liver (APASL)
convened an international working party on the management of hepatocellular carcinoma …

[HTML][HTML] A concise review of updated guidelines regarding the management of hepatocellular carcinoma around the world: 2010-2016

SJ Yu - Clinical and molecular hepatology, 2016 - ncbi.nlm.nih.gov
Many guidelines for hepatocellular carcinoma (HCC) have been published and updated
globally. In contrast to other cancers, there is a range of treatment options for HCC involving …

Design and endpoints of clinical trials in hepatocellular carcinoma

JM Llovet, AM Di Bisceglie, J Bruix… - Journal of the …, 2008 - academic.oup.com
The design of clinical trials in hepatocellular carcinoma (HCC) is complex because many
patients have concurrent liver disease, which can confound the assessment of clinical …