Engineered T cells that express chimeric antigen receptors (CARs) have transformed the
treatment of haematological cancers. CARs combine the tumour-antigen-binding function of …

There are 2 populations of T lymphocytes, αβ T and γδ T cells, that can be distinguished by
the expression of either an αβ TCR or a γδ TCR, respectively. Pairing of the Ag binding …

Initiation of T cell antigen receptor (TCR) signaling involves phosphorylation of CD3
cytoplasmic tails by the tyrosine kinase Lck. How Lck is recruited to the TCR to initiate …

The T‐cell receptor (TCR)–CD3 complex, expressed on T cells, determines the outcome of a
T‐cell response. It consists of the TCR‐αβ heterodimer and the non‐covalently associated …

The T cell receptor (TCR) is one of the most complicated receptors in mammalian cells, and
its triggering mechanism remains mysterious. As an octamer complex, TCR comprises an …

The αβ T‐cell receptor (TCR) is a multiprotein complex controlling the activation of T cells.
Although the structure of the complete TCR is not known, cumulative evidence supports that …

T cell receptor (TCR) is a kind of surface marker that are specific to T cells. The TCR
regulates T cell function and participates in the body's immunological response to prevent …

Advances in academic and clinical studies during the last several years have resulted in
practical outcomes in adoptive immune therapy of cancer. Immune cells can be programmed …

The non-catalytic region of tyrosine kinase (Nck) family of adaptors, consisting of Nck1 and
Nck2, contributes to selectivity and specificity in the flow of cellular information by recruiting …

The analysis of T cell lipid raft proteome is challenging due to the highly dynamic nature of
rafts and the hydrophobic character of raft-resident proteins. We explored an innovative …