Drug-induced liver injury

RJ Andrade, N Chalasani, ES Björnsson… - Nature Reviews …, 2019 - nature.com
Drug-induced liver injury (DILI) is an adverse reaction to drugs or other xenobiotics that
occurs either as a predictable event when an individual is exposed to toxic doses of some …

Genomics and drug response

L Wang, HL McLeod… - New England Journal of …, 2011 - Mass Medical Soc
Genomics and Drug Response | New England Journal of Medicine Skip to main content The New
England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology …

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin

AK Daly, PT Donaldson, P Bhatnagar, Y Shen, I Pe'er… - Nature …, 2009 - nature.com
Drug-induced liver injury (DILI) is an important cause of serious liver disease. The
antimicrobial agent flucloxacillin is a common cause of DILI, but the genetic basis for …

Risk factors for idiosyncratic drug-induced liver injury

N Chalasani, E Björnsson - Gastroenterology, 2010 - Elsevier
Idiosyncratic drug-induced liver injury (DILI) is a rare disorder that is not related directly to
dosage and little is known about individuals who are at increased risk. There are no suitable …

[HTML][HTML] Drug-induced liver injury: present and future

KT Suk, DJ Kim - Clinical and molecular hepatology, 2012 - ncbi.nlm.nih.gov
Liver injury due to prescription and nonprescription medications is a growing medical,
scientific, and public health problem. Worldwide, the estimated annual incidence rate of drug …

Mechanisms of adaptation and progression in idiosyncratic drug induced liver injury, clinical implications

L Dara, ZX Liu, N Kaplowitz - Liver International, 2016 - Wiley Online Library
In the past decade our understanding of idiosyncratic drug induced liver injury (IDILI) and
the contribution of genetic susceptibility and the adaptive immune system to the …

Herbal and dietary supplement-induced liver injuries in the Spanish DILI registry

I Medina-Caliz, M Garcia-Cortes… - Clinical …, 2018 - Elsevier
Background & Aims There have been increasing reports of liver injury associated with use of
herbal and dietary supplements, likely due to easy access to these products and beliefs …

Case characterization, clinical features and risk factors in drug-induced liver injury

A Ortega-Alonso, C Stephens, MI Lucena… - International Journal of …, 2016 - mdpi.com
Idiosyncratic drug-induced liver injury (DILI) caused by xenobiotics (drugs, herbals and
dietary supplements) presents with a range of both phenotypes and severity, from acute …

[PDF][PDF] Pharmacogenetics of drug‐induced liver injury

S Russmann, A Jetter, GA Kullak‐Ublick - Hepatology, 2010 - Wiley Online Library
Recent progress in research on drug‐induced liver injury (DILI) has been determined by key
developments in two areas. First, new technologies allow the identification of genetic risk …

Adverse drug reactions and organ damage: The liver

A Licata - European journal of internal medicine, 2016 - Elsevier
Drug-induced liver injury (DILI) is among the most challenging acute or chronic liver
conditions to be handled by physicians. Despite its low incidence in the general population …