Background Inheritance patterns show familial clustering of gastrointestinal cancers, and
multiple germline conditions have now been identified that predispose to colorectal, gastric …

Simple Summary Lynch syndrome is the most common cause of hereditary colorectal
cancer, but is also associated with increased extracolonic cancer risk, including upper …

Background and Aims Lynch syndrome (LS) predisposes affected individuals to a high
lifetime risk of malignancies, including colorectal, endometrial, gastric, and duodenal …

Lynch syndrome (LS) increases the risk of numerous different cancers including gastric
cancer. While some current guidelines recommend empiric gastric biopsies be performed …

Strong evidence demonstrates the protective benefit of frequent colonoscopy surveillance
for colorectal cancer prevention in Lynch Syndrome (LS) and is endorsed by many …

Small intestine-neuroendocrine tumors (SI-NETs) are one of the most common tumors of the
small bowel. Despite an increasing incidence, the exact mechanisms driving underlying …

DNA damage repair pathways, including mismatch repair (MMR) genes, are prone to
carcinoma development in certain patients. The assessment of the MMR system is widely …

In today's world, with its continuing advancements in genetics, the identification of Lynch
syndrome (LS) increasingly relies on sophisticated genetic testing techniques. Most …

Lynch syndrome (LS), the most common hereditary cause of colorectal cancer, predisposes
to upper gastrointestinal neoplasia. The prevalence of Barrett's esophagus (BE) is elevated …

Background In this review, we aimed to compare the recommendations for Lynch syndrome
(LS). Methods We compared the LS's guidelines of different medical societies, including …