Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

At high concentrations, free radicals and radical-derived, nonradical reactive species are
hazardous for living organisms and damage all major cellular constituents. At moderate …

The concept of differentiation therapy emerged from the fact that hormones or cytokines may
promote differentiation ex vivo, thereby irreversibly changing the phenotype of cancer cells …

Arsenicals are one of the oldest treatments for a variety of human disorders. Although
infamous for its toxicity, arsenic is paradoxically a therapeutic agent that has been used …

Detection of minimal residual disease (MRD) has proven to provide independent prognostic
information for treatment stratification in several types of leukemias such as childhood acute …

Nuclear architecture—the spatial arrangement of chromosomes and other nuclear
components—provides a framework for organizing and regulating the diverse functional …

Prospective studies on the detection of minimal residual disease (MRD) in acute leukemia
patients have shown that large-scale MRD studies are feasible and that clinically relevant …

Arsenic trioxide has shown substantial efficacy in treating both newly diagnosed and
relapsedpatients with acute promyelocytic leukemia (APL). As a single agent, it induces …

Although acute promyelocytic leukemia (APL) is one of the most characterized forms of
acute myeloid leukemia (AML), the molecular mechanisms involved in the development and …

A unique mRNA produced in leukemic cells from at (15; 17) acute promyelocytic leukemia
(APL) patient encodes a fusion protein between the retinoic acid receptor a (RARa) and a …