The concept of geroscience is that since ageing is the greatest risk factor for many diseases
and conditions, targeting the ageing process itself will have the greatest impact on human …

Ageing is a major risk factor for developing many neurodegenerative diseases. Cellular
senescence is a homeostatic biological process that has a key role in driving ageing. There …

Organismal ageing is a complex process driving progressive impairment of functionality and
regenerative potential of tissues. Cellular senescence is a state of stable cell cycle arrest …

Cellular senescence is defined as irreversible cell cycle arrest caused by various processes
that render viable cells non-functional, hampering normal tissue homeostasis. It has many …

Resveratrol and other natural stilbenoids, including piceatannol, pterostilbene, and gnetol,
are well-known anti-inflammatory compounds with indisputable activity in vitro as well as in …

The tumor microenvironment (TME) is a major contributor to cancer malignancy including
development of therapeutic resistance, a process mediated in part through intercellular …

Cellular senescence is a stress response mechanism ensuring homeostasis. Its temporal
activation during embryonic development or normal adult life is linked with beneficial …

Highlights•Senescent cells contribute to aging and age-related diseases.•Reducing the
secretory phenotype of senescent cells (SASP) has beneficial effects.•Elimination of …

Cellular senescence is a hallmark of aging, whose onset is linked to a series of both cell and
non-cell autonomous processes, leading to several consequences for the organism. To …

Aging is inevitable. Along with reduced ability to maintain the homeostasis of various
biological processes, aging gradually deteriorates overall health. Extensive research on the …