Clustered regularly interspaced short palindromic repeats-associated protein 9 (CRISPR–
Cas)-mediated genome editing has revolutionized biomedical research and will likely …

Autologous chimeric antigen receptor (CAR) T cells have changed the therapeutic
landscape in haematological malignancies. Nevertheless, the use of allogeneic CAR T cells …

To identify approaches to target DNA repair vulnerabilities in cancer, we discovered
nanomolar potent, selective, low molecular weight (MW), allosteric inhibitors of the …

The DNA mutation produced by cellular repair of a CRISPR–Cas9-generated double-strand
break determines its phenotypic effect. It is known that the mutational outcomes are not …

For more than a decade, it has been known that mammalian cells use shelterin to protect
chromosome ends. Much progress has been made on the mechanism by which shelterin …

DNA double-strand breaks (DSBs) are cytotoxic lesions that threaten genomic integrity.
Failure to repair a DSB has deleterious consequences, including genomic instability and cell …

DNA double-strand breaks (DSBs) disrupt the continuity of chromosomes and their repair by
error-free mechanisms is essential to preserve genome integrity. Microhomology-mediated …

Large-scale genomic studies have shown that half of epithelial ovarian cancers (EOCs)
have alterations in genes regulating homologous recombination (HR) repair. Loss of HR …

DNA is subject to many endogenous and exogenous insults that impair DNA replication and
proper chromosome segregation. DNA double-strand breaks (DSBs) are one of the most …

In this review, we discuss the repair of DNA double-strand breaks (DSBs) using a
homologous DNA sequence (ie, homologous recombination [HR]), focusing mainly on yeast …