How eukaryotic chromosomes fold inside the nucleus is an age-old question that remains
unanswered today. Early biochemical and microscopic studies revealed the existence of …

The spatial organization of chromosomes has long been connected to their polymeric nature
and is believed to be important for their biological functions, including the control of …

Discriminating the gene target of a distal regulatory element from other nearby transcribed
genes is a challenging problem with the potential to illuminate the causal underpinnings of …

Promoters are consensus DNA sequences located near the transcription start sites and they
play an important role in transcription initiation. Due to their importance in biological …

Whole-genome analysis approaches are identifying recurrent cancer-associated somatic
alterations in noncoding DNA regions. We combined somatic copy number analysis of 12 …

CCCTC-binding factor (CTCF) is critical to three-dimensional genome organization. Upon
differentiation, CTCF insulates active and repressed genes within Hox gene clusters. We …

Glioblastomas exhibit a hierarchical cellular organization, suggesting that they are driven by
neoplastic stem cells that retain partial yet abnormal differentiation potential. Here, we show …

Long noncoding RNAs (lncRNAs) represent an attractive class of candidates to mediate
cancer risk. Through integrative analysis of the lncRNA transcriptome with genomic data and …

Lineage-specific epigenomic changes during human corticogenesis have been difficult to
study owing to challenges with sample availability and tissue heterogeneity. For example …

Mutations in IDH1 and IDH2 (encoding isocitrate dehydrogenase 1 and 2) drive the
development of gliomas and other human malignancies. Mutant IDH1 induces epigenetic …