Despite tremendous efforts in the past two years, our understanding of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), virus–host interactions, immune …

The outbreaks of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) in 2019,
have highlighted the concerns about the lack of potential vaccines or antivirals approved for …

The development of new COX-2 inhibitors with analgesic and anti-inflammatory efficacy as
well as minimal gastrointestinal, renal and cardiovascular toxicity, is of vital importance to …

Recent efforts to repurpose drugs to combat COVID-19 have identified Remdesivir as a
candidate. It acts on the RNA-dependent, RNA polymerase (RdRp) of the SARS-CoV-2 …

RNA-dependent RNA polymerase (RdRp), also called nsp12, is considered a promising but
challenging drug target for inhibiting replication and hence, the growth of various RNA …

Promising inhibitory activities of the parasite multiplication were obtained upon evaluation of
in vivo antimalarial activities of new pyrazolylpyrazoline derivatives against Plasmodium …

Derivatives with tetrahydrobenzo [h] quinoline chemotype were synthesized via one-pot
reactions and evaluated for their antileishmanial, antimalarial and antitubercular activities …

The SARS CoV-2 pandemic has affected millions of people around the globe. Despite many
efforts to find some effective medicines against SARS CoV-2, no established therapeutics …

New spiro-piperidine derivatives were synthesised via the eco-friendly ionic liquids in a one-
pot fashion. The in vitro antileishmanial activity against Leishmania major promastigote and …

Resumen Context: COVID-19 pandemic has caused more than 2.7 million mortality
worldwide. Although the COVID-19 vaccine has been developed, the amount is still limited …