RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes,
including splicing, cleavage and polyadenylation, transport, translation and degradation of …

RNA-binding proteins (RBPs) play an important role in RNA metabolism, regulating the
stability, localization, and functional dynamics of RNAs. Alternation in the RBP-RNA network …

Understanding the pathogenic mechanisms of disease mutations is critical to advancing
treatments. ALS-associated mutations in the gene encoding the microtubule motor KIF5A …

Reactivation of fetal-specific genes and isoforms occurs during heart failure. However, the
underlying molecular mechanisms and the extent to which the fetal program switch occurs …

Abstract p53 plays a pivotal role in controlling the differentiation of mesenchymal stem cells
(MSCs) by regulating genes involved in cell cycle and early steps of differentiation process …

Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancer cases, with
more than 850,000 new diagnoses per year globally. Recent trends in the United States …

Background: Mutations in genes encoding sarcomeric proteins lead to failures in sarcomere
assembly, the building blocks of contracting muscles, resulting in cardiomyopathies that are …

Myocardial injury causes death to cardiomyocytes and leads to heart failure. The adult
mammalian heart has very limited regenerative capacity. However, the heart from early …

Lens transparency is established by abundant accumulation of crystallin proteins and loss of
organelles in the fiber cells. It requires an efficient translation of lens messenger RNAs …

RNA-binding proteins control the metabolism of RNAs at all stages of their lifetime. They are
critically required for the post-transcriptional regulation of gene expression in a wide variety …