Glutamate is the primary excitatory neurotransmitter in the central nervous system (CNS)
which initiates rapid signal transmission in the synapse before its re-uptake into the …

Schizophrenia is a chronic disorder characterized by specific positive and negative primary
symptoms, social behavior disturbances and cognitive deficits (eg, impairment in working …

Excitatory amino acid transporters (EAATs) encompass a class of five transporters with
distinct expression in neurons and glia of the central nervous system (CNS). EAATs are …

The brain exchanges nutrients and small molecules with blood via the blood–brain barrier
(BBB). Approximately 20% energy intake for the body is consumed by the brain. Glucose is …

Nonalcoholic fatty liver disease (NAFLD) is a pathology that contains a broad liver
dysfunctions spectrum. These alterations span from noninflammatory isolated steatosis until …

In the mammalian brain, glutamate is regarded to be the primary excitatory neurotransmitter
due to its widespread distribution and wide range of metabolic functions. Glutamate plays …

The excitatory amino acid transporter 2 (EAAT2) plays a key role in the clearance and
recycling of glutamate-the major excitatory neurotransmitter in the mammalian brain. EAAT2 …

Glycosylation is a common post-translational modification of brain proteins including cell
surface adhesion molecules, synaptic proteins, receptors and channels, as well as …

Preterm birth complications are the leading cause of child death worldwide and a top global
health priority. Among the survivors, the risk of life-long disabilities is high, including cerebral …

Cerebral ischemia/reperfusion (I/R) injury causes cognitive deficits, excitotoxicity,
neuroinflammation, oxidative stress and brain edema. Vitamin K2 (Menaquinone 4, MK-4) …