Obesity and leukemia: biological mechanisms, perspectives, and challenges

D Tsilingiris, NG Vallianou, N Spyrou… - Current Obesity …, 2024 - Springer
Abstract Purpose of Review To examine the epidemiological data on obesity and leukemia;
evaluate the effect of obesity on leukemia outcomes in childhood acute lymphoblastic …

Maternal body mass index, diabetes, and gestational weight gain and risk for pediatric cancer in offspring: a systematic review and meta-analysis

AR Marley, A Domingues, T Ghosh… - JNCI cancer …, 2022 - academic.oup.com
Background Pediatric cancer incidence has steadily increased concurrent with rising adult
obesity, but associations between maternal obesity and associated comorbidities and …

Adiponectin as a biomarker linking obesity and adiposopathy to hematologic malignancies

M Dalamaga, GS Christodoulatos - Hormone molecular biology and …, 2015 - degruyter.com
Higher body mass index and adiposopathy have been associated with increased risk of
hematologic malignancies such as leukemia, multiple myeloma, myeloproliferative …

Role of adiponectin in obesity related gastrointestinal carcinogenesis

GP Nagaraju, S Aliya, OB Alese - Cytokine & growth factor reviews, 2015 - Elsevier
Adiponectin is produced in the white adipose tissue and is known to have anti-metabolic
and anti-inflammatory properties. Serum/plasma adiponectin levels depend on diet, physical …

Is there a causal relationship between childhood obesity and acute lymphoblastic leukemia? A review

MJ Dushnicky, S Nazarali, A Mir, C Portwine… - Cancers, 2020 - mdpi.com
Simple Summary The childhood obesity epidemic is impacting tens of millions of children
globally. While obesity causes several cancers in adults, its potential role in causing …

Bioinformatics analysis and identification of hub genes and immune-related molecular mechanisms in chronic myeloid leukemia

F Yao, C Zhao, F Zhong, T Qin, S Li, J Liu, B Huang… - PeerJ, 2022 - peerj.com
Background Chronic myeloid leukemia (CML) is a malignant hyperplastic tumor of the bone
marrow originating from pluripotent hematopoietic stem cells. The advent of tyrosine kinase …

Obesity, bone marrow adiposity, and leukemia: Time to act

V Kumar, JH Stewart IV - Obesity Reviews, 2024 - Wiley Online Library
Obesity has taken the face of a pandemic with less direct concern among the general
population and scientific community. However, obesity is considered a low‐grade systemic …

Maternal obesity and acute lymphoblastic leukemia risk in offspring: A summary of trends, epidemiological evidence, and possible biological mechanisms

AR Marley, JR Ryder, LM Turcotte, LG Spector - Leukemia research, 2022 - Elsevier
Acute lymphoblastic leukemia, a heterogenous malignancy characterized by uncontrolled
proliferation of lymphoid progenitors and generally initiated in utero, is the most common …

Serum adiponectin levels are inversely correlated with leukemia: a meta-analysis

JJ Ma, J Shang, H Wang, JR Sui, K Liu… - Journal of cancer …, 2016 - journals.lww.com
Materials and Methods: Eligible studies were retrieved using both computerized and manual
searches. Relevant case-control studies were enrolled in strict accordance to our inclusion …

Adiponectin correlates with obesity: A study of 159 childhood acute leukemia survivors from India

R Srivastava, A Batra, A Tyagi, D Dhawan… - Indian journal of …, 2015 - journals.lww.com
Background: Acute lymphoblastic leukemia survivors are predisposed to obesity. However,
the exact underlying mechanisms are not known. AIMS: The study was done to assess the …