SGLT2 (sodium-glucose cotransporter 2) inhibitors produce a distinctive pattern of benefits
on the evolution and progression of cardiomyopathy and nephropathy, which is …

Mitochondria are dynamic organelles with multiple functions. They participate in necrotic cell
death and programmed apoptotic, and are crucial for cell metabolism and survival …

Abstract Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce heart failure events by
direct action on the failing heart that is independent of changes in renal tubular function. In …

Mitochondrial function is maintained by several strictly coordinated mechanisms, collectively
termed mitochondrial quality control mechanisms, including fusion and fission, degradation …

Abstract UNC-51-like kinase 1 (ULK1), as a serine/threonine kinase, is an autophagic
initiator in mammals and a homologous protein of autophagy related protein (Atg) 1 in yeast …

Intrauterine growth retardation (IUGR) is a major cause of perinatal morbidity and mortality.
Previous studies showed that 1-nitropyrene (1-NP), an atmospheric pollutant, induces …

Myocardial ischemia reduces the supply of oxygen and nutrients to cardiomyocytes, leading
to an energetic crisis or cell death. Mitochondrial dysfunction is a decisive contributor to the …

Hematopoietic stem cells (HSCs) reside at the top of the hematopoietic hierarchy, exhibiting
a unique capacity to self-renew and differentiate into all blood cells throughout the lifetime …

Pathological cardiac hypertrophy is an important cause of heart failure (HF). Recent studies
reveal that glucagon-like peptide-1 receptor (GLP1R) agonists can improve mortality and left …

Mitochondria play a key role in cellular metabolism. Mitochondrial dynamics (fusion and
fission) and mitophagy, are critical to mitochondrial function. Fusion allows organelles to …