Associations between cannabis use and psychotic outcomes are consistently reported, but
establishing causality from observational designs can be problematic. We review the …

Background Even low levels of substance misuse by people with a severe mental illness
can have detrimental effects. Objectives To assess the effects of psychosocial interventions …

BackgroundObservational associations between cannabis and schizophrenia are well
documented, but ascertaining causation is more challenging. We used Mendelian …

Use of amphetamine and methamphetamine is widespread in the general population and
common among patients with psychiatric disorders. Amphetamines may induce symptoms of …

Background The use of amphetamines is a global public health concern. We summarise
global data on use of amphetamines and mental health outcomes. Methods A systematic …

Methamphetamine is a potent psychostimulant that can induce psychosis among
recreational and chronic users, with some users developing a persistent psychotic syndrome …

Psychostimulant users are typically young adults. We have conducted a narrative review of
neuropsychiatric harms associated with the psychostimulants methamphetamine …

Background Previous voxel-based morphometric (VBM) and functional magnetic resonance
imaging (fMRI) studies have shown changes in brain structure and function in cocaine …

Background Psychosis can be associated with acute recreational drug and novel
psychoactive substance (NPS) toxicity. However, there is limited data available on how …

Presynaptic increase in striatal dopamine is the primary dopaminergic abnormality in
schizophrenia, but the underlying mechanisms are not understood. Here, we hypothesized …