Parkinson's disease (PD) is a common neurodegenerative disorder that primarily affects the
elderly. While the etiology of PD is likely multifactorial with the involvement of genetic …

Sphingolipids (SPLs) represent a highly diverse and structurally complex lipid class. The
discussion of SPL metabolism-related issues is of importance in understanding the …

A set of common-acting iron-responsive 5′ untranslated region (5′ UTR) motifs can fold
into RNA stem loops that appear significant to the biology of cognitive declines of …

Aging-induced neurodegenerative diseases (NDs) are significantly increasing health
problem worldwide. It has been well documented that oxidative stress is one of the potential …

Common variants in the iron regulatory protein HFE contribute to systematically increased
iron levels, yet the effects in the brain are not fully characterized. It is commonly believed that …

BACKGROUND: Intracerebral hemorrhage (ICH) is characterized by bleeding into the brain
parenchyma. During an ICH, iron released from the breakdown of hemoglobin creates a …

Recently, Parkinson's disease (PD) has become a remarkable burden on families and
society with an acceleration of population aging having several pathological hallmarks such …

Big data approaches have profoundly influenced state-of-the-art in many fields of research,
with toxicology being no exception. Here, we use Parkinson's disease as a window through …

The role of iron dyshomeostasis in neurodegenerative disease has implicated the
involvement of genes that regulate brain iron. The homeostatic iron regulatory gene (HFE) …

Aging and age-related diseases are important study topics due to their associations with
progressive physiological damage to genes, cells, tissues, and the entire organism, which …