Featured Application The focus of this review is the use of SEM imaging to gain insight into
the composition and morphology of minerals in view of predicting or understanding their …

ABSTRACT Early‐onset osteoporosis (EOOP), characterized by low bone mineral density
(BMD) and fractures, affects children, premenopausal women and men aged< 50 years …

A demanding task of the musculoskeletal system is the attachment of tendon to bone at
entheses. This region often presents a thin layer of fibrocartilage (FC), mineralized close to …

Not much is known about the time course of mineralization in newly formed bone from
healthy individuals nor in patients with bone disease. To investigate the early phase of …

The lacunocanalicular network (LCN) is an intricate arrangement of cavities (lacunae) and
channels (canaliculi), which permeates the mineralized bone matrix. In its porosity, the LCN …

Osteocytes are terminally differentiated osteoblasts embedded within the bone matrix and
key orchestrators of bone metabolism. However, they are generally not characterized by …

The spatial distribution of mineralization density is an important signature of bone growth
and remodeling processes, and its alterations are often related to disease. The extracellular …

Vitamin C (VitC) is essential for bone health, and low VitC serum levels increase the risk for
skeletal fractures. If and how VitC affects bone mineralization is unclear. Using micro …

ABSTRACT X‐linked hypophosphatemia (XLH) is characterized by excess fibroblast growth
factor 23 (FGF23) secretion, renal phosphate wasting, and low 1, 25 (OH) 2D3. Adult …

Abstract Purpose of Review Metabolic and genetic bone disorders affect not only bone mass
but often also the bone material, including degree of mineralization, matrix organization, and …