Importance Heterogeneous evidence exists for the association between COVID-19 and the
clinical outcomes of patients with mental health disorders. It remains unknown whether …

The tryptophan (TRP)-kynurenine (KYN) metabolic pathway is a main player of TRP
metabolism through which more than 95% of TRP is catabolized. The pathway is activated …

We examined whether inflammation is uniformly associated with all depressive and anxiety
symptoms, and whether these associations are potentially causal. Data was from 147,478 …

Research conducted over the past several decades has revolutionized our understanding of
the role of the immune system in neural and psychological development and function across …

Many patients with major depressive disorder (MDD) are reported to have higher levels of
multiple inflammatory cytokines including interleukin 6 (IL-6). Recent studies both pre …

Findings from numerous laboratories and across neuroimaging modalities have consistently
shown that exogenous administration of cytokines or inflammatory stimuli that induce …

Current medication for anxiety disorders is suboptimal in terms of efficiency and tolerability,
highlighting the need for improved drug treatments. In this review an overview of drugs …

Post-traumatic stress disorder (PTSD) has been associated with persistent, low-degree
inflammation, which could explain the increased prevalence of autoimmune conditions and …

Immune dysregulated cytokine production is involved in mental diseases. However, the
results are inconsistent and the pattern of cytokine alterations has not been compared …

Depression onset peaks during adolescence and young adulthood. Current treatments are
only moderately effective, driving the search for novel pathophysiological mechanisms …