Identification of potent inhibitors of NEK7 protein using a comprehensive computational approach
NIMA related Kinases (NEK7) plays an important role in spindle assembly and mitotic
division of the cell. Over expression of NEK7 leads to the progression of different cancers …
division of the cell. Over expression of NEK7 leads to the progression of different cancers …
Synthetic and Medicinal Perspective of 1, 2, 4‐Triazole as Anticancer Agents
Cancer is still one of the leading causes of death worldwide. Many researchers are working
to design and develop heterocyclic‐based drugs with the potential to treat cancer at various …
to design and develop heterocyclic‐based drugs with the potential to treat cancer at various …
[HTML][HTML] Search for New Compounds with Anti-Inflammatory Activity Among 1, 2, 4-Triazole Derivatives
T Glomb, J Minta, M Nowosadko, J Radzikowska… - Molecules, 2024 - mdpi.com
Compounds containing the 1, 2, 4-triazole moiety in their structure exhibit broad biological
activities. Many of these compounds demonstrate anti-inflammatory activity in vitro through …
activities. Many of these compounds demonstrate anti-inflammatory activity in vitro through …
Synthesis of tetracyclic spirooxindolepyrrolidine-engrafted hydantoin scaffolds: crystallographic analysis, molecular docking studies and evaluation of their …
A Toumi, FIA Abdella, S Boudriga, TYA Alanazi… - Molecules, 2023 - mdpi.com
In a sustained search for novel potential drug candidates with multispectrum therapeutic
application, a series of novel spirooxindoles was designed and synthesized via …
application, a series of novel spirooxindoles was designed and synthesized via …
Assessing p-tolyloxy-1, 3, 4-oxadiazole acetamides as lipoxygenase inhibitors assisted by in vitro and in silico studies
The underlying correlation between the inflammation, innate immunity and cancer is
extensively familiar and linked through a process mediated by three enzymes; …
extensively familiar and linked through a process mediated by three enzymes; …
Probing N-substituted 4-(5-mercapto-4-ethyl-4H-1, 2, 4-triazol-3-yl)-N-phenylpiperdine-1-carboxamides as potent 15-LOX inhibitors supported with ADME, DFT …
In our continuous efforts to find out leads against the enzyme 15-lipoxygenase (15-LOX), the
current study deals with the synthesis of a series of new N-alkyl/aralkyl/aryl derivatives of 2 …
current study deals with the synthesis of a series of new N-alkyl/aralkyl/aryl derivatives of 2 …
[HTML][HTML] Design, synthesis, in vitro and in silico studies of naproxen derivatives as dual lipoxygenase and α-glucosidase inhibitors
A Sardar, S Daud, M Fakhar-e-Alam… - Journal of Saudi …, 2022 - Elsevier
A series of 28 novel naproxen derivatives (4a-f, 5a-f, 6a-d, 7a-f, and 8a-f) have been
designed, synthesized, and characterized. The synthesized derivatives were assessed as …
designed, synthesized, and characterized. The synthesized derivatives were assessed as …
Parsing p-tolyloxy-1, 3, 4-oxadiazolepropanamides as 15-lipoxygenase inhibitors prop up by in vitro and in silico profiling including structure determination
In humans, tissue injury result in the production of an inflammatory response and
arachidonic acid released from the damaged membrane phospholipids is oxidized in two …
arachidonic acid released from the damaged membrane phospholipids is oxidized in two …
Vetting of new N-furfurylated p-chlorophenyl-1,2,4-triazole acetamides as lipoxygenase inhibitors assisted with in vitro and in silico studies
Anti-inflammatory agents inhibit cyclooxygenase (COX) enzymes or lipoxygenase (LOX)
enzymes to prevent inflammation implicated in various diseases including cancer. Non …
enzymes to prevent inflammation implicated in various diseases including cancer. Non …
Targeting new N-furfurylated 4-chlorophenyl-1,2,4-triazolepropionamide hybrids as potential 15-lipoxygenase inhibitors supported with in vitro and in silico studies
Lipoxygenases (LOXs) are a group of enzymes that catalyze the oxidation of
polyunsaturated fatty acids and initiate the biosynthesis of secondary metabolites that are …
polyunsaturated fatty acids and initiate the biosynthesis of secondary metabolites that are …