CAR T cells for brain tumors: Lessons learned and road ahead
Malignant brain tumors, including glioblastoma, represent some of the most difficult to treat
of solid tumors. Nevertheless, recent progress in immunotherapy, across a broad range of …
of solid tumors. Nevertheless, recent progress in immunotherapy, across a broad range of …
Genetic modification of cytokine signaling to enhance efficacy of CAR T cell therapy in solid tumors
N Ghahri-Saremi, B Akbari, T Soltantoyeh… - Frontiers in …, 2021 - frontiersin.org
Chimeric antigen receptor (CAR) T cell therapy has shown unprecedented success in
treating advanced hematological malignancies. Its effectiveness in solid tumors has been …
treating advanced hematological malignancies. Its effectiveness in solid tumors has been …
CAR T cell therapy: newer approaches to counter resistance and cost
Abstract The genetically engineered Chimeric Antigen Receptor bearing T-cell (CAR T cell)
therapy has been emerged as the new paradigm of cancer immunotherapy. However, recent …
therapy has been emerged as the new paradigm of cancer immunotherapy. However, recent …
CAR T-cell therapy for B-cell lymphomas: outcomes and resistance mechanisms
Chimeric antigen receptor (CAR) T cells are an exciting curative intent approach to the
treatment of non-Hodgkin lymphomas (NHLs). Several products have received FDA …
treatment of non-Hodgkin lymphomas (NHLs). Several products have received FDA …
The induction of a permissive environment to promote T cell immune evasion in acute myeloid leukemia: The metabolic perspective
D Mougiakakos - Frontiers in oncology, 2019 - frontiersin.org
Acute myeloid leukemia (AML) is the acute leukemia with highest incidence amongst adults.
Despite significant improvements in understanding the genomic landscape and the …
Despite significant improvements in understanding the genomic landscape and the …
Engineering solutions for mitigation of chimeric antigen receptor T-Cell dysfunction
A Gavriil, M Barisa, E Halliwell, J Anderson - Cancers, 2020 - mdpi.com
The clinical successes of chimeric antigen receptor (CAR)-T-cell therapy targeting cell
surface antigens in B cell leukaemias and lymphomas has demonstrated the proof of …
surface antigens in B cell leukaemias and lymphomas has demonstrated the proof of …
Engineering chimeric antigen receptor signaling architectures for T cell immunotherapies
R Castellanos Rueda - 2024 - research-collection.ethz.ch
Chimeric Antigen Receptors (CARs) are rationally designed synthetic receptors that are
engineered to redirect the specificity and effector function of T lymphocytes toward a target …
engineered to redirect the specificity and effector function of T lymphocytes toward a target …
[图书][B] Transcription Factor Modulation in T-Cells to Improve Cancer Immunotherapy
AB Wilkens - 2022 - search.proquest.com
Adoptive transfer of T-cells expressing chimeric antigen receptors (CAR-T) effectively treats
refractory hematologic malignancies in a subset of patients, but can be limited by the …
refractory hematologic malignancies in a subset of patients, but can be limited by the …
The Impact of Myeloid-Mediated Co-Stimulation and Immunosuppression on the Anti-Tumor Efficacy of Adoptive T cell Therapy
PP Innamarato - 2020 - search.proquest.com
Adoptive T cell therapy (ACT) in combination with lymphodepleting chemotherapy is an
effective strategy to induce the eradication of tumors, providing long-term regression in …
effective strategy to induce the eradication of tumors, providing long-term regression in …