A second transmissible cancer in Tasmanian devils

RJ Pye, D Pemberton, C Tovar… - Proceedings of the …, 2016 - National Acad Sciences
Clonally transmissible cancers are somatic cell lineages that are spread between
individuals via the transfer of living cancer cells. There are only three known naturally …

Using genomics to characterize evolutionary potential for conservation of wild populations

KA Harrisson, A Pavlova, M Telonis‐Scott… - Evolutionary …, 2014 - Wiley Online Library
Genomics promises exciting advances towards the important conservation goal of
maximizing evolutionary potential, notwithstanding associated challenges. Here, we explore …

Immunology of naturally transmissible tumours

HV Siddle, J Kaufman - Immunology, 2015 - Wiley Online Library
Naturally transmissible tumours can emerge when a tumour cell gains the ability to pass as
an infectious allograft between individuals. The ability of these tumours to colonize a new …

Reversible epigenetic down-regulation of MHC molecules by devil facial tumour disease illustrates immune escape by a contagious cancer

HV Siddle, A Kreiss, C Tovar… - Proceedings of the …, 2013 - National Acad Sciences
Contagious cancers that pass between individuals as an infectious cell line are highly
unusual pathogens. Devil facial tumor disease (DFTD) is one such contagious cancer that …

The devil is in the details: Genomics of transmissible cancers in Tasmanian devils

A Storfer, PA Hohenlohe, MJ Margres, A Patton… - PLoS …, 2018 - journals.plos.org
Cancer poses one of the greatest human health threats of our time. Fortunately, aside from a
few rare cases of cancer transmission in immune-suppressed organ transplant recipients [1] …

Targeted gene flow for conservation

E Kelly, BL Phillips - Conservation biology, 2016 - Wiley Online Library
Anthropogenic threats often impose strong selection on affected populations, causing rapid
evolutionary responses. Unfortunately, these adaptive responses are rarely harnessed for …

Regression of devil facial tumour disease following immunotherapy in immunised Tasmanian devils

C Tovar, RJ Pye, A Kreiss, Y Cheng, GK Brown… - Scientific reports, 2017 - nature.com
Devil facial tumour disease (DFTD) is a transmissible cancer devastating the Tasmanian
devil (Sarcophilus harrisii) population. The cancer cell is the 'infectious' agent transmitted as …

Variants in the host genome may inhibit tumour growth in devil facial tumours: evidence from genome-wide association

B Wright, CE Willet, R Hamede, M Jones, K Belov… - Scientific reports, 2017 - nature.com
Devil facial tumour disease (DFTD) has decimated wild populations of Tasmanian devils
(Sarcophilus harrisii) due to its ability to avoid immune detection and pass from host to host …

Transmissible cancer in Tasmanian devils: localized lineage replacement and host population response

RK Hamede, AM Pearse, K Swift… - … of the Royal …, 2015 - royalsocietypublishing.org
Tasmanian devil facial tumour disease (DFTD) is a clonally transmissible cancer threatening
the Tasmanian devil (Sarcophilus harrisii) with extinction. Live cancer cells are the infectious …

The newly-arisen Devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer

A Caldwell, R Coleby, C Tovar, MR Stammnitz… - Elife, 2018 - elifesciences.org
Devil Facial Tumour 2 (DFT2) is a recently discovered contagious cancer circulating in the
Tasmanian devil (Sarcophilus harrisii), a species which already harbours a more …