New mechanistic insights of melasma

W Liu, Q Chen, Y Xia - Clinical, cosmetic and investigational …, 2023 - Taylor & Francis
Melasma is a common acquired disorder of pigmentation that negatively impacts quality of
life. Present treatments show poor therapeutic effect with frequent recurrence. This in large …

[HTML][HTML] A spotlight on the role of copper in the epithelial to mesenchymal transition

A Focaccio, L Rossi, A De Luca - Life Sciences, 2024 - Elsevier
The complex process known as epithelial to mesenchymal transition (EMT) plays a
fundamental role in several biological settings, encompassing embryonic development …

Rab7a is an enhancer of TPC2 activity regulating melanoma progression through modulation of the GSK3β/β-Catenin/MITF-axis

C Abrahamian, R Tang, R Deutsch… - Nature …, 2024 - nature.com
Melanoma arising from pigment-producing melanocytes is the deadliest form of skin cancer.
Extensive ultraviolet light exposure is a major cause of melanoma and individuals with low …

MiR-182 is upregulated in prostate cancer and contributes to tumor progression by targeting MITF

MYC Stafford, DJ McKenna - International Journal of Molecular Sciences, 2023 - mdpi.com
Altered expression of microRNA-182-5p (miR-182) has been consistently linked with many
cancers, but its specific role in prostate cancer remains unclear. In particular, its contribution …

[HTML][HTML] Ginsenoside Re inhibits melanogenesis and melanoma growth by downregulating microphthalmia-associated transcription factor

SJ Hwang, HJ Bang, HJ Lee - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Panax ginseng, also known as Korean ginseng, is a traditional remedy widely used in Asian
countries. Its major active compounds are ginsenosides, specifically triterpenoid saponins …

Genomic analysis reveals the association of KIT and MITF variants with the white spotting in swamp buffaloes

D Dai, EM Sari, J Si, H Ashari, MIA Dagong… - BMC genomics, 2024 - Springer
Background Swamp-type buffaloes with varying degrees of white spotting are found
exclusively in Tana Toraja, South Sulawesi, Indonesia, where spotted buffalo bulls are …

[HTML][HTML] Reversing gray hair: inspiring the development of new therapies through research on hair pigmentation and repigmentation progress

Z Feng, Y Qin, G Jiang - International Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Hair graying is a common and visible sign of aging resulting from decreased or absence of
melanogenesis. Although it has been established that gray hair greatly impacts people's …

Tumor microenvironment as a therapeutic target in melanoma treatment

N Kharouf, TW Flanagan, SY Hassan, H Shalaby… - Cancers, 2023 - mdpi.com
Simple Summary As a solid tumor, melanoma is not only a tumor mass of monolithic tumor
cells, but it also contains supporting stroma, extracellular matrix (ECM), and soluble …

[HTML][HTML] Uveal melanoma: current evidence on prognosis, treatment and potential developments

MC Gelmi, MJ Jager - Asia-Pacific Journal of Ophthalmology, 2024 - Elsevier
Uveal Melanoma (UM) is a rare disease, yet it is the most common primary intraocular
malignancy in adult patients. Despite continuous advancements and research, the risk of …

The assessment of anti-melanoma potential of tigecycline—cellular and molecular studies of cell proliferation, apoptosis and autophagy on amelanotic and melanotic …

J Rok, J Kowalska, Z Rzepka, D Stencel, A Skorek… - Cells, 2023 - mdpi.com
High mortality, aggressiveness, and the relatively low effectiveness of therapy make
melanoma the most dangerous of skin cancers. Previously published studies presented the …