Genetic studies have typically inferred the effects of human impact by documenting patterns
of genetic differentiation and levels of genetic diversity among potentially isolated …

Host restriction factors are potent, widely expressed intracellular blocks to viral replication
that are an important component of the innate immune response to viral infection. However …

Functional diversity of the highly polymorphic human leukocyte antigen class I (HLA-I) genes
underlies successful immunologic control of both infectious disease and cancer. The …

This comprehensive, groundbreaking book on the biodiversity of parasites offers a clear and
accessible explanation of how parasite biodiversity provides insight into the history and …

A selective advantage against infectious disease associated with increased heterozygosity
at the human major histocompatibility complex [human leukocyte antigen (HLA) class I and …

The complex correlation structure of a collection of orthologous DNA sequences is uniquely
captured by the “ancestral recombination graph”(ARG), a complete record of coalescence …

The major histocompatibility complex (MHC) has become a paradigm for how selection can
act to maintain adaptively important genetic diversity in natural populations. Here, we review …

The emerging amphibian disease chytridiomycosis is caused by the fungal pathogen
Batrachochytrium dendrobatidis (Bd). Amphibian populations and species differ in …

Genetic resistance to infectious diseases is likely to involve a complex array of immune-
response and other genes with variants that impose subtle but significant consequences on …

Genome assemblies are currently being produced at an impressive rate by consortia and
individual laboratories. The low costs and increasing efficiency of sequencing technologies …