J. Neurochem.(2010) 113, 576–590. Abstract The discovery of a Sonic Hedgehog (Shh)
signaling pathway in the mature vertebrate CNS has paved the way to the characterization …

Sonic hedgehog (Shh) signaling influences neurogenesis and neural patterning during the
development of central nervous system. Dysregulation of Shh signaling in brain leads to …

Scope Adult hippocampal neurogenesis is a lifelong feature of brain plasticity that appears
to be critically involved in adult brain function and neurological disease. Recent studies …

Autism is a multifactorial neurodevelopmental condition; it demonstrates some main
characteristics, such as impaired social relationships and increased repetitive behavior. The …

Like the liver or other peripheral organs, two regions of the adult brain possess the ability of
self-renewal through a process called neurogenesis. This raises tremendous hope for …

Stroke is a devastating neurovascular disease with limited therapeutic options. The
pathogenesis of stroke involves complex interrelated molecular mechanisms including …

Depression is one of the most prevalent and crucial public health problem connected to
significant mortality and co-morbidity. Recently, numerous studies suggested that dietary …

Thyroid hormone is important for development and plasticity in the immature and adult
mammalian brain. Several thyroid hormone-responsive genes are regulated during specific …

There are various theories to explain the pathophysiology of depression and support its
diagnosis and treatment. The roles of monoamines, brain‐derived neurotrophic factor …

Anamniotes, fishes and amphibians, have the capacity to regenerate spinal cord tissue after
injury, generating new neurons that mature and integrate into the spinal circuitry. Elucidating …