Neuronal and synaptic plasticity are widely used terms in the field of psychiatry. However,
cellular neurophysiologists have identified two broad classes of plasticity. Hebbian forms of …

MDGA (MAM domain containing glycosylphosphatidylinositol anchor) family proteins were
previously identified as synaptic suppressive factors. However, various genetic …

Summary Calcium (Ca 2+) signaling is tightly regulated within a presynaptic bouton. Here,
we visualize Ca 2+ signals within hippocampal presynaptic boutons using GCaMP8s tagged …

The spatial distribution of proteins and their arrangement within the cellular ultrastructure
regulates the opening of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) …

MAGUK scaffold proteins play a central role in maintaining and modulating synaptic
signaling, providing a framework to retain and position receptors, signaling molecules, and …

Synapses maintain two forms of neurotransmitter release to support communication in the
brain. First, evoked neurotransmitter release is triggered by the invasion of an action …

Brain-derived neurotrophic factor (BDNF) plays a critical role in synaptic physiology, as well
as mechanisms underlying various neuropsychiatric diseases and their treatment. Despite …

Synaptic vesicles can undergo several modes of exocytosis, endocytosis, and trafficking
within individual synapses, and their fates may be linked to differences in the vesicular …

Understanding the function of glutamate transporters has broad implications for explaining
how neurons integrate information and relay it through complex neuronal circuits. Most of …

The quantal content of an evoked postsynaptic response is typically determined by dividing
it by the average spontaneous miniature response. However, this approach is challenged by …