Cancer is a group of diseases in which cells divide continuously and excessively. Cell
division is tightly regulated by multiple evolutionarily conserved cell cycle control …

The altered activation or overexpression of protein kinases (PKs) is a major subject of
research in oncology and their inhibition using small molecules, protein kinases inhibitors …

Background Acquisition of the chemoresistance to docetaxel (DTX), a microtubule-targeting
agent, has been a huge obstacle in treatment for metastatic castration-resistant prostate …

Background Drugs targeting the spindle assembly checkpoint (SAC), such as inhibitors of
Aurora kinase B (AURKB) and dual specific protein kinase TTK, are in different stages of …

DNA Topoisomerase IIA (Topo IIA) is an enzyme that alters the topological state of DNA and
is essential for the separation of replicated sister chromatids and the integrity of cell division …

Genome instability has been identified as one of the enabling hallmarks in cancer. DNA
damage response (DDR) network is responsible for maintenance of genome integrity in …

Cancer is a systemic manifestation of aberrant cell cycle activity and dysregulated cell
growth. Genetic mutations can determine tumor onset by either augmenting cell division …

The aurora kinase is a key enzyme that is implicated in tumor growth. Research revealed
that small molecules that target aurora kinase have beneficial effects as anticancer agents …

Discovery of cancer risk variants in the sequence of the germline genome can shed light on
carcinogenesis. Here we describe gene burden association analyses, aggregating rare …

Breast cancer is the most common malignancy in women worldwide and despite significant
advancements in detection, treatment, and management of cancer, it is still the leading …