Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine
The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
Growth cone travel in space and time: the cellular ensemble of cytoskeleton, adhesion, and membrane
EA Vitriol, JQ Zheng - Neuron, 2012 - cell.com
Growth cones, found at the tip of axonal projections, are the sensory and motile organelles
of developing neurons that enable axon pathfinding and target recognition for precise wiring …
of developing neurons that enable axon pathfinding and target recognition for precise wiring …
Self-amplifying autocrine actions of BDNF in axon development
A critical step in neuronal development is the formation of axon/dendrite polarity, a process
involving symmetry breaking in the newborn neuron. Local self-amplifying processes could …
involving symmetry breaking in the newborn neuron. Local self-amplifying processes could …
Phosphoinositides: regulators of nervous system function in health and disease
Phosphoinositides, the seven phosphorylated derivatives of phosphatidylinositol have
emerged as regulators of key sub-cellular processes such as membrane transport …
emerged as regulators of key sub-cellular processes such as membrane transport …
Lipids shape brain function through ion channel and receptor modulations: physiological mechanisms and clinical perspectives
S Incontro, ML Musella, M Sammari… - Physiological …, 2025 - journals.physiology.org
Lipids represent the most abundant molecular type in the brain, with a fat content of∼ 60%
of the dry brain weight in humans. Despite this fact, little attention has been paid to …
of the dry brain weight in humans. Despite this fact, little attention has been paid to …
Primary cilia signaling promotes axonal tract development and is disrupted in Joubert syndrome-related disorders models
Appropriate axonal growth and connectivity are essential for functional wiring of the brain.
Joubert syndrome-related disorders (JSRD), a group of ciliopathies in which mutations …
Joubert syndrome-related disorders (JSRD), a group of ciliopathies in which mutations …
Establishing neuronal polarity with environmental and intrinsic mechanisms
S Yogev, K Shen - Neuron, 2017 - cell.com
Neurons are among the most morphologically complex cells. A distinction between two
compartments, axon and dendrite, generates cellular domains that differ in membrane …
compartments, axon and dendrite, generates cellular domains that differ in membrane …
Phosphoinositides signaling modulates microglial actin remodeling and phagocytosis in Alzheimer's disease
SE Desale, S Chinnathambi - Cell Communication and Signaling, 2021 - Springer
Alzheimer's disease is one of the neurodegenerative diseases, characterized by the
accumulation of abnormal protein deposits, which disrupts signal transduction in neurons …
accumulation of abnormal protein deposits, which disrupts signal transduction in neurons …
The essential role of primary cilia in cerebral cortical development and disorders
Primary cilium, first described in the 19th century in different cell types and organisms by
Alexander Ecker, Albert Kolliker, Aleksandr Kowalevsky, Paul Langerhans, and Karl …
Alexander Ecker, Albert Kolliker, Aleksandr Kowalevsky, Paul Langerhans, and Karl …
TRPs in the brain
The Transient receptor potential (TRP) family of cation channels is a large protein family,
which is mainly structurally uniform. Proteins consist typically of six transmembrane domains …
which is mainly structurally uniform. Proteins consist typically of six transmembrane domains …