Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

The liver is a highly dynamic metabolic organ that plays critical roles in plasma protein
synthesis, gluconeogenesis and glycogen storage, cholesterol metabolism and bile acid …

The transcription factor NRF2 is the master regulator of the cellular antioxidant response.
Though recognized originally as a target of chemopreventive compounds that help prevent …

Autophagy is a self-eating catabolic pathway that contributes to liver homeostasis through its
role in energy balance and in the quality control of the cytoplasm, by removing misfolded …

Enhanced de novo lipogenesis mediated by sterol regulatory element–binding proteins
(SREBPs) is thought to be involved in nonalcoholic steatohepatitis (NASH) pathogenesis. In …

Abstract The Nrf2-Keap1-ARE pathway is a redox and xenobiotic sensitive signaling axis
that functions to protect cells against oxidative stress, environmental toxicants, and harmful …

Autophagy is a highly conserved process that degrades certain intracellular contents in both
physiological and pathological conditions. Autophagy-related proteins (ATG) are key players …

Macroautophagy (autophagy hereafter) recycles intracellular components to sustain
mitochondrial metabolism that promotes the growth, stress tolerance, and malignancy of …

Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the
West. In mice, APAP hepatotoxicity can be rapidly induced with a single dose. Because it is …

Drug-induced liver injury (DILI) presents unique challenges for consumers, clinicians, and
regulators. It is the most common cause of acute liver failure in the US. It is also one of the …