Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has
been a major focus of oncology research. The p53 protein is a transcription factor that can …

Rational design of chimeric antigen receptor T (CAR-T) cells based on the recognition of
antigenic epitopes capable of evoking the most potent CAR activation is an important …

Lassa virus (LASV) infection is expanding outside its traditionally endemic areas in West
Africa, posing a pandemic biothreat. LASV-neutralizing antibodies, moreover, have proven …

The infectious severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the
causative agent for coronavirus disease 2019 (COVID-19). Globally, there have been …

SARS-CoV-2 is the etiological agent of the COVID-19 pandemic. Antibody-based
therapeutics targeting the spike protein, specifically the S1 subunit or the receptor binding …

Global health and economy are deeply influenced by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) and its newly emerging variants. Nanobodies with nanometer …

Here we interrogate the factors responsible for SARS-CoV-2 breakthrough infections in a
K18-hACE2 transgenic mouse model. We show that Delta and the closely related Kappa …

Nanobodies (Nbs) are one of the most promising therapeutics for overcoming immune
escape in various diseases, including SARS‐CoV‐2 infection and cancers. However, the …

A phagemid is a plasmid that contains the origin of replication and packaging signal of a
filamentous phage. Following bacterial transformation, a phagemid can be replicated and …