Mendelian randomization refers to an analytic approach to assess the causality of an
observed association between a modifiable exposure or risk factor and a clinically relevant …

Vitamin D is a precursor of the steroid hormone calcitriol that is crucial for bone and mineral
metabolism. Both the high prevalence of vitamin D deficiency in the general population and …

Background The association between vitamin E and cancer risk has been widely
investigated by observational studies, but the findings remain inconclusive. Here, we aimed …

The recent successful genome-wide association studies (GWASs) for depression have
yielded more than 80 replicated loci and brought back the excitement that had evaporated …

With the rapidly increasing availability of large genetic data sets in recent years, Mendelian
Randomization (MR) has quickly gained popularity as a novel secondary analysis method …

Background: Adiposity traits have been associated with risk of many cancers in
observational studies, but whether these associations are causal is unclear. Mendelian …

Background Endometriosis is recognized as a complex gynecological disorder that can
cause severe pain and infertility, affecting 6–10% of all reproductive-aged women …

Background Triggering receptor expressed on myeloid cell 1 (Trem1) is an important
regulator of cellular inflammatory responses. Neuroinflammation is a common thread across …

Objective Although the association between obesity and risk of rheumatic disease is well
established, the precise causal relation has not been conclusively proven. Here, we …

Research on genetic influences on human fertility outcomes such as number of children
ever born (NEB) or the age at first childbirth (AFB) has been solely based on twin and family …