The influenza virus polymerase complex: an update on its structure, functions, and significance for antiviral drug design
A Stevaert, L Naesens - Medicinal research reviews, 2016 - Wiley Online Library
Influenza viruses cause seasonal epidemics and pandemic outbreaks associated with
significant morbidity and mortality, and a huge cost. Since resistance to the existing anti …
significant morbidity and mortality, and a huge cost. Since resistance to the existing anti …
Corona virus versus existence of human on the earth: A computational and biophysical approach
Z Zehra, M Luthra, SM Siddiqui, A Shamsi… - International Journal of …, 2020 - Elsevier
SARS-CoV-2 has a positive sense RNA genome of 29.9 kb in size, showing high sequence
similarity to the BAT-CoV, SARS-CoV, MERS-CoV. SARS-CoV-2 is composed of 14 open …
similarity to the BAT-CoV, SARS-CoV, MERS-CoV. SARS-CoV-2 is composed of 14 open …
Bunyaviridae RNA Polymerases (L-Protein) Have an N-Terminal, Influenza-Like Endonuclease Domain, Essential for Viral Cap-Dependent Transcription
Bunyaviruses are a large family of segmented RNA viruses which, like influenza virus, use a
cap-snatching mechanism for transcription whereby short capped primers derived by …
cap-snatching mechanism for transcription whereby short capped primers derived by …
Structural analysis of specific metal chelating inhibitor binding to the endonuclease domain of influenza pH1N1 (2009) polymerase
E Kowalinski, C Zubieta, A Wolkerstorfer… - PLoS …, 2012 - journals.plos.org
It is generally recognised that novel antiviral drugs, less prone to resistance, would be a
desirable alternative to current drug options in order to be able to treat potentially serious …
desirable alternative to current drug options in order to be able to treat potentially serious …
The N-terminal domain of the arenavirus L protein is an RNA endonuclease essential in mRNA transcription
Arenaviridae synthesize viral mRNAs using short capped primers presumably acquired from
cellular transcripts by a 'cap-snatching'mechanism. Here, we report the crystal structure and …
cellular transcripts by a 'cap-snatching'mechanism. Here, we report the crystal structure and …
Structural basis for the identification of the N-terminal domain of coronavirus nucleocapsid protein as an antiviral target
SY Lin, CL Liu, YM Chang, J Zhao… - Journal of medicinal …, 2014 - ACS Publications
Coronaviruses (CoVs) cause numerous diseases, including Middle East respiratory
syndrome and severe acute respiratory syndrome, generating significant health-related and …
syndrome and severe acute respiratory syndrome, generating significant health-related and …
Sequence, structure and functional diversity of PD-(D/E) XK phosphodiesterase superfamily
K Steczkiewicz, A Muszewska, L Knizewski… - Nucleic acids …, 2012 - academic.oup.com
Proteins belonging to PD-(D/E) XK phosphodiesterases constitute a functionally diverse
superfamily with representatives involved in replication, restriction, DNA repair and tRNA …
superfamily with representatives involved in replication, restriction, DNA repair and tRNA …
Structural and biochemical basis for development of influenza virus inhibitors targeting the PA endonuclease
RM DuBois, PJ Slavish, BM Baughman, MK Yun… - PLoS …, 2012 - journals.plos.org
Emerging influenza viruses are a serious threat to human health because of their pandemic
potential. A promising target for the development of novel anti-influenza therapeutics is the …
potential. A promising target for the development of novel anti-influenza therapeutics is the …
Understanding the Structure–Activity Relationship through Density Functional Theory: A Simple Method Predicts Relative Binding Free Energies of Metalloenzyme …
Despite being involved in several human diseases, metalloenzymes are targeted by a small
percentage of FDA-approved drugs. Development of novel and efficient inhibitors is …
percentage of FDA-approved drugs. Development of novel and efficient inhibitors is …
Bibenzyls and bisbybenzyls of bryophytic origin as promising source of novel therapeutics: pharmacology, synthesis and structure-activity
S Nandy, A Dey - DARU Journal of Pharmaceutical Sciences, 2020 - Springer
Background The amphibian, non-vascular, gametophyte-dominant, bio-indicator class,
bryophytes; with their wide ranges of habitat have attained importance due to their promising …
bryophytes; with their wide ranges of habitat have attained importance due to their promising …