In human pathophysiology, the clash between microbial infection and host immunity
contributes to multiple diseases. Cystic fibrosis (CF) is a classical example of this …

On-line analysis of exhaled breath offers insight into a person's metabolism without the need
for sample preparation or sample collection. Due to its noninvasive nature and the possibility …

The airways of patients with cystic fibrosis (CF) are nearly always infected with many
different microorganisms. This environment offers warm, humid and nutrient-rich conditions …

Background Bronchiectasis develops early in the course of cystic fibrosis, being detectable
in infants as young as 10 weeks of age, and is persistent and progressive. We sought to …

Bacteria survive in nature by forming biofilms on surfaces and probably most, if not all,
bacteria (and fungi) are capable of forming biofilms. A biofilm is a structured consortium of …

The persistence of chronic Pseudomonas aeruginosa lung infections in cystic fibrosis (CF)
patients is due to biofilm-growing mucoid (alginate-producing) strains. A biofilm is a …

Lung infection is the main cause of morbidity and mortality in patients with cystic fibrosis and
is mainly dominated by Pseudomonas aeruginosa. The biofilm mode of growth makes …

SUMMARY A select group of microorganisms inhabit the airways of individuals with cystic
fibrosis. Once established within the pulmonary environment in these patients, many of …

Almost two decades after CFTR was identified as the gene responsible for cystic fibrosis
(CF), we still lack answers to many questions about the pathogenesis of the disease, and it …

Lung disease causes most of the morbidity and mortality in cystic fibrosis (CF).
Understanding the pathogenesis of this disease has been hindered, however, by the lack of …