The mechanisms underlying the progression of diabetes mellitus and heart failure are
closely intertwined, such that worsening of one condition is frequently accompanied by …

1436 Circulation April 21, 2015 demand arising secondary to the loss of ventricular tissue. In
both cases, when the pressure overload state is persistent, the hypertrophic phenotype of …

The beating heart possesses intrinsic ability to adapt cardiac output to changes in
mechanical load. The century-old Frank-Starling law and Anrep effect have documented that …

The Frank–Starling mechanism of the heart is due, in part, to modulation of myofilament
Ca2+ sensitivity by sarcomere length (SL)[length-dependent activation (LDA)]. The …

Objective: This study aims to describe the pharmacodynamics of a fluid challenge over a 10-
minute period in postoperative patients. Design: Prospective observational study. Setting …

Despite significant efforts to predict and prevent right heart failure, it remains a leading
cause of morbidity and mortality after implantation of left ventricular assist systems (LVAS). In …

Critically ill patients with the need for mechanical ventilation show complex interactions
between respiratory and cardiovascular physiology. These interactions are important as they …

Cardiomyocytes contract against a mechanical load during each heartbeat, and excessive
mechanical stress leads to heart diseases. Using a cell-in-gel system that imposes an …

Importance Before the introduction of 3-dimensional echocardiography, estimations of right
ventricular (RV) size and function by echocardiography were limited to regional …

Heart failure (HF) is associated with elevated sympathetic tone and mechanical load. Both
systems activate signaling transduction pathways that increase cardiac output, but …