Although it is broadly agreed that the improved treatment of patients with cancer will depend
on a deeper molecular understanding of the underlying pathogenesis, only a few examples …

Bacteria communicate with one another using chemical signal molecules. As in higher
organisms, the information supplied by these molecules is critical for synchronizing the …

Growth factors and their transmembrane receptor tyrosine kinases play important roles in
cell proliferation, survival, migration and differentiation. One group of growth factors …

The epidermal growth factor (EGF)-related peptides bind the ErbB receptors, inducing the
formation of different homo-and heterodimers. Receptor dimerization promotes activation of …

The polytopic membrane protein Rhomboid-1 promotes the cleavage of the membrane-
anchored TGFα-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor …

Receptor and cytoplasmic protein tyrosine kinases play prominent roles in the control of a
range of cellular processes during embryonic development and in the regulation of many …

Background Gut homeostasis is central to whole organism health, and its disruption is
associated with a broad range of pathologies. Following damage, complex physiological …

Targeted mice lacking functional EGF or amphiregulin (AR) were derived and bred to the
TGFα-knockout to generate mice lacking various combinations of the three ligands. In …

Directed cell migrations are important for development, but the signaling pathways and
mechanisms responsible for guiding cell migration in vivo are poorly understood. Migration …

The malaria parasite Plasmodium falciparum infects 5–10% of the world's population and
kills two million people annually. Fatalities are thought to result in part from pathological …