The causes of neurodegenerative diseases are complex with likely contributions from
genetic susceptibility and environmental exposures over an organism's lifetime. In this …

Human neocortex controls and integrates higher brain processes including cognition,
emotions, perception and complex behaviors. Aberrant cortical development can be …

Segmentation of the vertebrate hindbrain leads to the formation of rhombomeres, each with
a distinct anteroposterior identity. Specialised boundary cells form at segment borders that …

Robust brain development requires the tight coordination between tissue growth, neuronal
differentiation and stem cell maintenance. To achieve this, neural stem cells need to balance …

During central nervous system (CNS) development, neural progenitor cells (NPCs) generate
neurons and glia in two different ways. In direct neurogenesis, daughter cells differentiate …

The ability of the nervous system to detect a wide range of noxious stimuli is crucial to avoid
life-threatening injury and to trigger protective behavioral and physiological responses. Pain …

During early spinal cord development, neurons of particular subtypes differentiate with a
sparse periodic pattern while later neurons differentiate in the intervening space to …

ABSTRACT A conserved feature of the central nervous system (CNS) is the prominent
expansion of anterior regions (brain) compared with posterior (nerve cord). The cellular and …

Maintenance of the neural progenitor pool during embryonic development is essential to
promote growth of the central nervous system (CNS). The CNS is initially formed by tightly …

Fetal alcohol syndrome (FASD) describes a range of birth defects. Mechanisms of FASD-
associated defects are not well understood. It has great significance to investigate whether …