PROTEIN SECRETORY PATHWAYS: A GENERAL OUTLINE Leader and leaderless
secretory proteins Most secretory proteins are synthesized as precursors carrying a leader …

Neuropeptide Y (NPY) was first discovered and characterized as a 36‐amino‐acid peptide
neurotransmitter in 1982. It is widely distributed in the central nervous system, with …

Five novel peptides were identified in the brains of mice lacking active carboxypeptidase E,
a neuropeptide-processing enzyme. These peptides are produced from a single precursor …

We have cloned and sequenced a mouse cDNA encoding the 793-residue amino acid
sequence of furin, which is a protein homologous to the yeast Kex2 protease. The entire …

We previously demonstrated that C75, a specific and potent inhibitor of fatty acid synthase
(FAS), reduced food intake and decreased body weight in mice. In the present study, we …

It is becoming clear that astrocytes are active participants in synaptic functioning and exhibit
properties, such as the secretion of classical transmitters, previously thought to be …

Soluble proteins which reside in the lumen of the endoplasmic reticulum share a common
carboxyl-terminal tetrapeptide Lys-Asp-Glu-Leu (KDEL). Addition of the tetrapeptide to a …

To investigate trafficking in neuroendocrine cells, green fluorescent protein (GFP) tags were
fused to various portions of the preproneuropeptide Y (NPY) precursor. Two neuroendocrine …

We have investigated the role of the somatostatin propeptide in mediating intracellular
transport and sorting to the regulated secretory pathway. Using a retroviral expression …

PACE4 is one of the neuroendocrine-specific mammalian subtilisin-related endoproteases
believed to function in the secretory pathway. The biosynthesis and secretion of PACE4 …