T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

Organ development and homeostasis involve dynamic interactions between individual cells
that collectively regulate tissue architecture and function. To ensure the highest tissue …

The diverse leukocyte infiltrate in atherosclerotic mouse aortas was recently analyzed in 9
single-cell RNA sequencing and 2 mass cytometry studies. In a comprehensive meta …

Recent evidence has elucidated how multipotent blood progenitors transform their identities
in the thymus and undergo commitment to become T cells. Together with environmental …

A complete chart of cis-regulatory elements and their dynamic activity is necessary to
understand the transcriptional basis of differentiation and function of an organ system. We …

MicroRNAs (miRNAs) are crucial post-transcriptional regulators of haematopoietic cell fate
decisions. They act by negatively regulating the expression of key immune development …

Helper T (Th) cell subsets direct immune responses by producing signature cytokines. Th2
cells produce IL-4, IL-5, and IL-13, which are important in humoral immunity and protection …

The last decade has witnessed great advances in our understanding of the genetic and
biological basis of childhood acute lymphoblastic leukemia (ALL), the development of …

Recent single-cell analysis technologies offer an unprecedented opportunity to elucidate
developmental pathways. Here we present Wishbone, an algorithm for positioning single …

The production of autologous T cells expressing a chimaeric antigen receptor (CAR) is time-
consuming, costly and occasionally unsuccessful. T-cell-derived induced pluripotent stem …