Epigenetic aberrations, which are recognized as key drivers of several human diseases, are
often caused by genetic defects that result in functional deregulation of epigenetic proteins …

Inhibitors of histone deacetylases (HDACs) are nowadays part of the therapeutic arsenal
mainly against cancers, with four compounds approved by the Food and Drug …

Histone deacetylase 8 (HDAC8) is a class I histone deacetylase implicated as a therapeutic
target in various diseases, including cancer, X-linked intellectual disability, and parasitic …

Runt-related transcription factor 1 (RUNX1) is generally considered to function as a tumor
suppressor in the development of leukemia, but a growing body of evidence suggests that it …

The histone deacetylases (HDACs) enzymes provided crucial role in transcriptional
regulation of cells through deacetylation of nuclear histone proteins. Discoveries related to …

Histone deacetylase 8 (HDAC8), a unique class I zinc-dependent HDAC, is an emerging
target in cancer and other diseases. Its substrate repertoire extends beyond histones to …

The first two differentiation events in the embryo result in three cell types–epiblast,
trophectoderm (TE) and hypoblast. The purpose here was to identify molecular markers for …

In the natural cellular environment, nucleic acid biomolecules like DNA have biological
implications via structural modifications and through precise coordination with other …

Recent innovations in cutting-edge sequencing platforms have allowed the rapid
identification of genes associated with communicable, noncommunicable and rare diseases …

The influential role of the epigenome in orchestrating genome-wide transcriptional activation
instigates the demand for the artificial genetic switches with distinct DNA sequence …