The possible mechanisms of Cu and Zn in the treatment and prevention of HIV and COVID-19 viral infection

SA Albalawi, RA Albalawi, AA Albalawi… - … Trace Element Research, 2024 - Springer
Due to their unique properties and their potential therapeutic and prophylactic applications,
heavy metals have attracted the interest of many researchers, especially during the outbreak …

Autophagy of the ER: the secretome finds the lysosome

J Knupp, ML Pletan, P Arvan, B Tsai - The FEBS journal, 2023 - Wiley Online Library
Lysosomal degradation of the endoplasmic reticulum (ER) and its components through the
autophagy pathway has emerged as a major regulator of ER proteostasis. Commonly …

Multifaceted Nature of Lipid Droplets in Viral Interactions and Pathogenesis

L Herrera-Moro Huitron, LA De Jesús-González… - Microorganisms, 2023 - mdpi.com
Once regarded as inert organelles with limited and ill-defined roles, lipid droplets (LDs) have
emerged as dynamic entities with multifaceted functions within the cell. Recent research has …

Interferon-stimulated gene TDRD7 interacts with AMPK and inhibits its activation to suppress viral replication and pathogenesis

S Chakravarty, G Subramanian, S Popli… - Mbio, 2023 - Am Soc Microbiol
Many viruses activate cellular autophagy in infected cells to facilitate their replication.
Recently, we identified an interferon (IFN)-stimulated gene (ISG) Tudor domain containing 7 …

FAM46C Is an Interferon-Stimulated Gene That Inhibits Lentiviral Particle Production by Modulating Autophagy

M Mancino, G Lai, F De Grossi, A Cuomo… - Microbiology …, 2023 - Am Soc Microbiol
ABSTRACT FAM46C is a multiple myeloma (MM) tumor suppressor whose function is only
starting to be elucidated. We recently showed that in MM cells FAM46C triggers apoptosis by …

Autophagy and SARS-CoV-2-old players in new games

T Ivanova, Y Mariienko, N Mehterov… - International Journal of …, 2023 - mdpi.com
At present it is well-defined that autophagy is a fundamental process essential for cell life but
its pro-viral and anti-viral role has been stated out with the COVID pandemic. However …

Interplay between autophagy and herpes simplex virus type 1: ICP34. 5, one of the main actors

I Ripa, S Andreu, JA López-Guerrero… - International Journal of …, 2022 - mdpi.com
Herpes simplex virus type 1 (HSV-1) is a neurotropic virus that occasionally may spread to
the central nervous system (CNS), being the most common cause of sporadic encephalitis …

Protein Quality Control Systems and ER Stress as Key Players in SARS-CoV-2-Induced Neurodegeneration

E Gavilán, R Medina-Guzman… - Cells, 2024 - mdpi.com
The COVID-19 pandemic has brought to the forefront the intricate relationship between
SARS-CoV-2 and its impact on neurological complications, including potential links to …

Crosstalk Between Innate Immunity and Autophagy in Viral Myocarditis Leading to Dilated Cardiomyopathy

C Wang, H Luo - Reviews in Medical Virology, 2024 - Wiley Online Library
Viral myocarditis, characterised by inflammation of the heart muscle, presents a significant
challenge to global public health, particularly affecting younger individuals and often …

An LIR motif in the Rift Valley fever virus NSs protein is critical for the interaction with LC3 family members and inhibition of autophagy

K Petraccione, MGH Ali, N Cyr, HM Wahba… - Plos …, 2024 - journals.plos.org
Rift Valley fever virus (RVFV) is a viral zoonosis that causes severe disease in ruminants
and humans. The nonstructural small (NSs) protein is the primary virulence factor of RVFV …