Understanding how chromatin is organized within the nucleus and how this 3D architecture
influences gene regulation, cell fate decisions and evolution are major questions in cell …

The different cell types of an organism share the same DNA, but during cell differentiation
their genomes undergo diverse structural and organizational changes that affect gene …

The basic biology of the cell division cycle and its control by protein kinases was originally
studied through genetic and biochemical studies in yeast and other model organisms. The …

In 2007, 1179 papers were published that involved the application of optical biosensors.
Reported developments in instrument hardware, assay design, and immobilization …

Here we present ComPPI, a cellular compartment-specific database of proteins and their
interactions enabling an extensive, compartmentalized protein–protein interaction network …

Posttranslational histone modifications regulate both gene expression and genome integrity.
Despite the dynamic nature of these modifications, appropriate real-time monitoring systems …

Background Following amputation, urodele salamander limbs reprogram somatic cells to
form a blastema that self-organizes into the missing limb parts to restore the structure and …

Kinases of the Aurora family are essential for the proper execution of mitosis in eukaryotes,
and Aurora inhibitors are in clinical trials as anticancer drugs. We applied site-specific …

Spontaneous intracerebral hemorrhage (ICH) is a devastating disease with high morbidity
and mortality worldwide. We have previously shown that ferroptosis contributes to neuronal …

The efficiency and outcome of CRISPR/Cas9 editing depends on the chromatin state at the
cut site. It has been shown that changing the chromatin state can influence both the …