Few scientific contributions have made significant impact unless there was a champion who
had the vision to see the potential for its use in seemingly disparate areas—and who then …

Optimal Design for Nonlinear Response Models discusses the theory and applications of
model-based experimental design with a strong emphasis on biopharmaceutical studies …

It is not trivial to conduct clinical trials with pediatric participants. Ethical, logistical, and
financial considerations add to the complexity of pediatric studies. Optimal design theory …

Several developments have facilitated the practical application and increased the general
use of optimal design for nonlinear mixed effects models. These developments include new …

Nonlinear mixed effect models (NLMEM) with multiple responses are increasingly used in
pharmacometrics, one of the main examples being the joint analysis of the pharmacokinetics …

Population pharmacokinetic (PK)–pharmacodynamic (PKPD) models are increasingly used
in drug development and in academic research; hence, designing efficient studies is an …

We extend the methodology for designs evaluation and optimization in nonlinear mixed
effects models with an illustration of the decrease of human immunodeficiency virus viral …

The methods of experimental design described in the majority of the earlier chapters are
appropriate if the continuous response, perhaps after transformation, has independent …

Sensor networks have recently come into prominence because they hold the potential to
revolutionize a wide spectrum of both civilian and military applications. An ingenious …

Non‐linear mixed‐effects models (NLMEMs) are used to improve information gathering from
longitudinal studies and are applied to treatment evaluation in disease‐evolution studies …