Human organoid models to study SARS-CoV-2 infection
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history. SARS …
syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history. SARS …
Microbiota and COVID-19: Long-term and complex influencing factors
J Gang, H Wang, X Xue, S Zhang - Frontiers in Microbiology, 2022 - frontiersin.org
The coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). According to the World Health …
respiratory syndrome coronavirus 2 (SARS-CoV-2). According to the World Health …
TMPRSS2 expression dictates the entry route used by SARS‐CoV‐2 to infect host cells
J Koch, ZM Uckeley, P Doldan, M Stanifer… - The EMBO …, 2021 - embopress.org
SARS‐CoV‐2 is a newly emerged coronavirus that caused the global COVID‐19 outbreak in
early 2020. COVID‐19 is primarily associated with lung injury, but many other clinical …
early 2020. COVID‐19 is primarily associated with lung injury, but many other clinical …
[HTML][HTML] A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells
It is not well understood why diabetic individuals are more prone to develop severe COVID-
19. To this, we here established a human kidney organoid model promoting early hallmarks …
19. To this, we here established a human kidney organoid model promoting early hallmarks …
A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses
Rapid identification of host genes essential for virus replication may expedite the generation
of therapeutic interventions. Genetic screens are often performed in transformed cell lines …
of therapeutic interventions. Genetic screens are often performed in transformed cell lines …
Enteric coronavirus infection and treatment modeled with an immunocompetent human intestine-on-a-chip
Many patients infected with coronaviruses, such as SARS-CoV-2 and NL63 that use ACE2
receptors to infect cells, exhibit gastrointestinal symptoms and viral proteins are found in the …
receptors to infect cells, exhibit gastrointestinal symptoms and viral proteins are found in the …
COVID19 Disease Map, a computational knowledge repository of virus–host interaction mechanisms
We need to effectively combine the knowledge from surging literature with complex datasets
to propose mechanistic models of SARS‐CoV‐2 infection, improving data interpretation and …
to propose mechanistic models of SARS‐CoV‐2 infection, improving data interpretation and …
Mechanisms leading to gut dysbiosis in COVID-19: current evidence and uncertainties based on adverse outcome pathways
LA Clerbaux, J Filipovska, A Muñoz, M Petrillo… - Journal of clinical …, 2022 - mdpi.com
Alteration in gut microbiota has been associated with COVID-19. However, the underlying
mechanisms remain poorly understood. Here, we outlined three potential interconnected …
mechanisms remain poorly understood. Here, we outlined three potential interconnected …
Antiviral responses in a Jamaican fruit bat intestinal organoid model of SARS-CoV-2 infection
M Hashimi, TA Sebrell, JF Hedges, D Snyder… - Nature …, 2023 - nature.com
Bats are natural reservoirs for several zoonotic viruses, potentially due to an enhanced
capacity to control viral infection. However, the mechanisms of antiviral responses in bats …
capacity to control viral infection. However, the mechanisms of antiviral responses in bats …
[HTML][HTML] Induced dysregulation of ACE2 by SARS-CoV-2 plays a key role in COVID-19 severity
ME Mehrabadi, R Hemmati, A Tashakor… - Biomedicine & …, 2021 - Elsevier
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the cause of COVID-19, is
reported to increase the rate of mortality worldwide. COVID-19 is associated with acute …
reported to increase the rate of mortality worldwide. COVID-19 is associated with acute …